Inhibition by α-amanitin of the oestradiol-induced increase in α-amanitin insensitive RNA polymerase in immature rat uterus
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INHIBITION BY a-AMANITIN OF THE OESTRADIOLINDUCED INCREASE IN a-AMANITIN INSENSITIVE RNA POLYMERASE IN IMMATURE RAT UTERUS
The injection of oestradiol to the prepuberal or castrated rat results, 2-3 hr later, in a large increase in RNA biosynthesis [l] and in an increased ability of uterine nuclei to incorporate nucleoside triphosphates into RNA [2]. Various reports have established that oestrogen-stimulated RNA is largely of ribosomal nature [3,4] . Recently, two different classes of DNAdependent RNA polymerases h...
متن کاملSpecific Inhibition of Nuclear RNA Polymerase II by α-Amanitin Author(s):
a-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a compl...
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29 M. W r i s c h e r , Z. Pflanzenphysiol. 55, 296 [1966]. Teile des Lamellarsystems der Chloropiasten wieder in Plastidenzentren umgewandelt werden 29. Die che mischen Analysen haben nun gezeigt, daß in den Plastidenzentren der Etioplasten und im Lamellar system der Chloroplasten die gleichen farblosen Lipide Vorkommen. Ihr Mengenverhältnis ist jedoch in den beiden Formen des Membransystems...
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Our laboratory has developed methods for transient state kinetic analysis of human RNA polymerase II elongation. In these studies, multiple conformations of the RNA polymerase II elongation complex were revealed by their distinct elongation potential and differing dependence on nucleoside triphosphate substrate. Among these are conformations that appear to correspond to different translocation ...
متن کاملThe Action of Α-amanitin on Rna Synthesis in Chinese Hamster Ovary Cells
alpha-Amanitin acts in vitro as a selective inhibitor of the nucleoplasmic form B RNA polymerases. Treatment of Chinese hamster ovary (CHO) cells with this drug leads principally to a severe fragmentation of the nucleoli. While the ultrastructural lesions induced by alpha-amanitin in CHO cells and in rat or mouse liver are quite similar, the results diverge concerning the effect on RNA synthesi...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1972
ISSN: 0014-5793
DOI: 10.1016/0014-5793(72)80228-x